The Saint Mary's Academy Building is a historic building in the Lawrenceville neighborhood of Pittsburgh, Pennsylvania.

Built in 1854, it is a notable example of Greek Revival architecture and one of the neighborhood's only surviving buildings dating to the pre–Civil War era.

St. Mary's merged with three other Lawrenceville parishes (Holy Family, St. Augustine, and St. John the Baptist) in 1993 to form the new Our Lady of Angels parish.

The St. Mary church buildings remained in use for a few years but closed in 2004.

The association planned to raze the Academy building to provide more room for burials, but the building was nominated as a Pittsburgh historic landmark to protect it from demolition.