Saint Matthew and the Angel (1602) is a painting from the Italian master Caravaggio (1571–1610), completed for the Contarelli Chapel in the church of San Luigi dei Francesi in Rome.

A part of the collection of the former Kaiser Friedrich Museum, it was moved to a flak tower for safety but was destroyed by fire at the end of World War II while stored in an anti-aircraft bunker in Berlin.

Cardinal Del Monte played a major part in orchestrating the decoration of its interior, and was the one who suggested Caravaggio as the painter of the scenes of Saint Matthew's life.

[3] However, the church was not pleased with the statue and Caravaggio was re-hired to do another piece as the center for the altar, to show Saint Matthew writing the Gospel under the guidance of an angel.

The comparison is not perfect because the only images available of the lost Saint Matthew and the Angel are black and white photographs that were taken before World War II.

Nevertheless, the surviving version loses the touching directness of the first - the childlike angel patiently guiding the Saint's hand on the page as though he were the child.