Along with her sister, Saint Pudentiana, she provided for the poor and gave care and comfort to persecuted Christians and martyrs.

Praxedes' father was Saint Pudens, a Roman senator who was a Christian convert of St. Peter, mentioned in the New Testament by St. Paul in 2 Timothy 4:21.

[6] They cared for, encouraged, financially supported, and comforted Christians, hid many in Praxedes' home, ministered to them in prison, and buried martyrs.

[3][4][5] Praxedes is depicted in images at the basilica "squeezing the blood of the martyrs which she has collected from a sponge into a vessel".

[3] A part of the floor in the basilica's central nave is marked as the place where the sisters' relics are stored.