Saint Rosalie Interceding for the Plague-stricken of Palermo is a painting of 1624 by Anthony van Dyck, in the Metropolitan Museum of Art in New York since 1871.

The painting was one of six of Saint Rosalia produced in Palermo by van Dyck in the late summer of 1624 and early 1625, when the city was quarantined.

It was an early acquisition by the institution, whose curators initially mistook it for an Assumption of the Virgin.

[4] The saint's remains (she died in 1166) were said to have been found on Mount Pellegrino on 15 July 1624, the same year as the painting was executed.

In recent years, using the technique of radiography based on neutron emission, it has been discovered that for this particular painting, van Dyck re-used a canvas which had previously borne a sketch for a self-portrait.