It is located at West 15th Street and South Normandie Avenue in the Byzantine-Latino Quarter[1] This Greek Orthodox church is the result of a Hollywood success story.

The cathedral still draws its predominantly Greek congregation of as many as 1,000 from perhaps a 60-mile radius – from throughout Los Angeles and Orange Counties.

Members of the church congregation have included Hollywood actors such as Telly Savalas, whose funeral was held there.

In rapper Ice Cube's 1993 music video "It Was a Good Day", the church can be seen in the background of the basketball scene.

The church featured in Season 3, Episode 10 of Nip/Tuck (“Madison Berg”) as the location for Christian and Kimber’s wedding.