The hospital sees 21,388 total admissions and 32,000 emergency department visits annually.

In June 2009, Saint Thomas Hospital was recognized with a 2009/2010 HealthGrades Outstanding Patient Experience Award.

[12] Saint Thomas Hospital was opened in Nashville by the Daughters of Charity.

It moved to its current campus, some 4 miles (6.4 km) west of the original, in 1972.

[14] In the fall of 2012, the hospital's outpatient neurosurgery unit, along with two other pain treatment centers in Tennessee (Specialty Surgery Center, Crossville; PCA Pain Care Center, Oak Ridge) and cases from other states (especially Virginia, Florida and Maryland) was affected by a non-contagious, fungal (Aspergillosis) strain of meningitis (fungal meningitis).