[7] The original lineup consisted of Dave Chandler (guitar), Mark Adams (bass), Armando Acosta (drums) and Scott Reagers (vocals).

[8] After breaking up in 1996 and briefly reforming in 2003, Saint Vitus reunited again in 2008 with the band's "classic" lineup, featuring Weinrich, Chandler, Adams and Acosta, and embarked on a successful tour.

By 2016, both Weinrich and Adams had left Saint Vitus and were replaced by Reagers and Pat Bruders respectively, leaving Chandler as the only constant member of the band and reuniting half of the original lineup.

[12] In the beginning, their style was considered "out-of-date" compared to the hardcore punk, glam and speed metal genres, which were popular at the time.

Black Flag guitarist Greg Ginn signed them to his label, SST Records, because, according to Chandler, they were "completely opposite of what popular was in metal".

[9] Saint Vitus toured with Black Flag during the early 1980s,[14][15][16][17] and later with other groups like the Brood, Saccharine Trust, the Mentors, Napalm Beach and DC3.

Reagers' final performances featured songs from then-upcoming album Born Too Late, such as "The War Starter" and "H.A.A.G", as many of these were written while he was still in the band.

[20] The Wino years marked a change in their style, featuring an even slower and darker sound, in contrast to the hardcore influences of the first two records with Reagers, and the band started to gain some notoriety in Europe.

[20] Weinrich also wrote some songs such as "Bitter Truth", "Looking Glass" and "Ice Monkey", the latter was covered by supergroup Down in their early live performances.

Following Weinrich's departure, the band found former Count Raven singer Christian "Chritus" Linderson as a replacement after a short search.

After The Obsessed broke up in the mid-1990s, Wino moved back to Maryland and formed Shine/Spirit Caravan and once again toured Europe and the US until the band's break up in the early 2000s.

Wino also briefly joined Place of Skulls, featuring former Pentagram/Death Row guitarist Victor Griffin, for the album With Vision released in 2003.

On July 1, 2003, the classic Born Too Late lineup (Weinrich, Chandler, Adams, Acosta) played a gig at Double Door in Chicago.

"[29] In March 2010, Wino revealed to the German edition of Metal Hammer magazine that Saint Vitus were without a record label, and had only written one new song so far, but that a full-length studio effort from the group would likely surface within the next 12 months, making a 2011 release date likely.

"[35] In 2015, Saint Vitus performed a single U.S. date in Austin, Texas and a European tour with original singer Scott Reagers, his first full shows with the band in 20 years.

[36] Due to Wino's commitments with The Obsessed's reunion, Reagers once again filled in for him on Saint Vitus' fall 2016 U.S. tour with The Skull and Witch Mountain[37][38] and has remained with the band ever since.

Also during this period, Pat Bruders of Crowbar and Down filled in for their longtime bassist Mark Adams, who could not tour with the band because of health reasons; it was revealed in October 2018 that he had been suffering from Parkinson's disease.