[1] Saint Xavier University was founded as a women's college by the Sisters of Mercy in 1846 at the request of Bishop William Quarter.

[6] Saint Xavier's 109 acres (44.1 ha) main campus is located in City of Chicago in the Mt.

These residence halls are environmentally friendly, featuring rooftop gardens and clean-source alternative energy.

In 2021, Saint Xavier celebrated its 175th anniversary and received an official state resolution honoring its legacy in Chicago.

The university is a member of the National Association of Intercollegiate Athletics (NAIA), primarily competing in the Chicagoland Collegiate Athletic Conference (CCAC) in most of its sports since the 1973–74 academic year; while its football team competes in the Midwest League of the Mid-States Football Association (MSFA).