Sainte-Colombe (French pronunciation: [sɛ̃t kɔlɔ̃b] ⓘ; Gallo: Saentt-Cólonbb-an-la-Méy, Breton: Santez-Koulm) is a commune in the Ille-et-Vilaine department in Brittany in northwestern France.

Inhabitants of Sainte-Colombe are called colombins in French.

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