Sainte-Colombe (French pronunciation: [sɛ̃t kɔlɔ̃b] ⓘ; Arpitan: Sente-Colomba), sometimes referred to as Sainte-Colombe-lès-Vienne, is a commune in the Rhône department in eastern France.

Occupied since Roman times, it is across the Rhône river from Vienne.

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