Sainte-Colombe (French pronunciation: [sɛ̃t kɔlɔ̃b] ⓘ) is a commune in the Seine-et-Marne department in the Île-de-France region in north-central France.

Sainte-Colombe–Septveilles station has rail connections to Provins, Longueville and Paris.

Inhabitants of Sainte-Colombe are called Saint-Colombinois.

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