Sainte-Hénédine (French pronunciation: [sɛ̃t enedin]) is a parish municipality in La Nouvelle-Beauce Regional County Municipality in the Chaudière-Appalaches region of Quebec, Canada.

It is named after Catherine-Hénédine Dionne, widow of Pierre-Elzéar Taschereau, who owned the two seigneuries from which the territory of Sainte-Hénédine was detached.

Sainte-Hénédine forms part of the federal electoral district of Beauce and has been represented by Richard Lehoux of the Conservative Party since 2019.

Provincially, Sainte-Hénédine is part of the Beauce-Nord electoral district and is represented by Luc Provençal of the Coalition Avenir Québec since 2018.

The parish town council consists of 5 councilors and a mayor.