The Sainte-Marie (French pronunciation: [sɛ̃t maʁi] ⓘ) neighbourhood is located in the eastern edge of the Centre-Sud area, in the borough of Ville-Marie.

Prior to the construction of the Maison Radio-Canada, the area was part of the working-class neighborhood popularly known as Faubourg à m'lasse, demolished in the 1960s.

[1] Sainte-Marie, and the Centre-Sud more broadly, have a long held reputation for poverty, organized crime and prostitution[2][3][4][5][6][7] casting the neighbourhood in a negative light.

[12] Sainte-Marie is part of the larger Centre-Sud, its boundaries are roughly De Lorimier Avenue to the west, the CP rails to the east, Sherbrooke Street to the north and the St. Lawrence River to the south.

A notable landmark in the area is the JTI MacDonald tobacco company, which has been located on Ontario Street for many decades.