Sainte-Marie-Salomé (French pronunciation: [sɛ̃t maʁi salɔme]) is a municipality in the Lanaudière region of Quebec, Canada, part of the Montcalm Regional County Municipality.

In 1765, the first wave of colonization occurred as a result of the Great Upheaval when Acadians from Boston arrived and settled on the south bank of the Vacher Creek (French: ruisseau Vacher) in the Seignory of Saint-Sulpice.

The settlement was called Bas-du-Ruisseau-Vacher (meaning "Lower Vacher Creek"), named after a certain Vacher who accompanied surveyor John Péladeau in 1767 on the seignory's territory.

[5] In 1888, the parish municipality of Sainte-Marie-Salomé was established by separating from Saint-Jacques-de-l'Achigan, and named after Mary Salome.

[5] Population trend:[6] Private dwellings occupied by usual residents: 516 (total dwellings: 542) Mother tongue: Being in the fertile land of the St. Lawrence Lowlands, agriculture is the most important economic function of the municipality.