Sainte-Marie-aux-Mines (French pronunciation: [sɛ̃t maʁi o min] ⓘ; German: Markirch; Alsatian: Màrkìrisch) is a commune in the Haut-Rhin department and Grand Est region of north-eastern France.

Nearby Lorraine is accessible by road over the Col de Sainte-Marie (772 metres; 2533') or the Tunnel Maurice-Lemaire (reopened, following a major upgrade, in October 2008).

Sélestat in the Bas Rhin, a much more substantial commercial and political focus for the region, is just 26 km (16 mi) to the east, along the Liepvrette valley.

Some 23 km (15 miles) to the west lies Sélestat at the intersection of the D48, D416, and D459 roads, the first of which crosses the Col des Bagenelles mountain pass.

In Louis XIV's "Armorial de la Généralité d’Alsace", Sainte-Marie-aux-Mines's coat of arms is described as: a blue field with a silver-colored representation of Our Lady putting her feet on a golden mountain.

These arms evoke both the geographic and political situation of the town prior to the French Revolution and the mining industry for which it was famous.

The first mention of the town dates from the time of Theodoric II, Duke of Lorraine, who returned in 1078 to Lièpvre's convent Sainte-Marie-aux-Mines's tithes and that of the Saint Blaise's nearby village.

Gérard d'Alsace descended from the family who reigned over Alsace in the 7th century, the name of which is connected with that of Etichon which was also the father of Sainte Odile.

The new hereditary Duke of Lorraine, Gérard d'Alsace, belonged so to an illustrious lineage solidly provided in Alsace, that is in the southwest of the realm of Germania.

Monk of Wissembourg, convent is which possesses properties to the south of the former duchy, not far from Sélestat, and appears to have shown for this region a very deep interest.

Sainte-Marie-aux-Mines, levy in Latin Sancte Maria ad Fodinas, and in German Markirch, owes her name and her origin to exploitation of mines and to the church of Sainte Marie Madeleine who was the parish of the part of Lorraine and who was built in 1757.

Eddie Slovik, the only U.S. soldier of World War II to be executed for desertion, suffered the fate by firing squad near the town on 31 January 1945.