Sainte-Séraphine (French pronunciation: [sɛ̃t seʁafin]) is a parish municipality located in the Centre-du-Québec region of Quebec, Canada.

In the 2021 Census of Population conducted by Statistics Canada, Sainte-Séraphine had a population of 441 living in 176 of its 224 total private dwellings, a change of 24.2% from its 2016 population of 355.

With a land area of 75.86 km2 (29.29 sq mi), it had a population density of 5.8/km2 (15.1/sq mi) in 2021.

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