Sainte-Soulle (French pronunciation: [sɛ̃t sul]) is a commune in the Charente-Maritime department in the Nouvelle-Aquitaine region in southwestern France.

It is traversed by the N11 (La Rochelle - Paris), which can be accessed at the Usseau roundabout.

At the Usseau roundabout, the route connecting La Rochelle with Nantes (N137) branches off the N11.

Apart from the village Sainte-Soulle, the commune consists of the localities Les Grandes-Rivières, Les Petites-Rivières, Saint-Coux, part of Fontpatour, le Treuil-Arnaudeau, Usseau, La Gabardelière, Chavagne and Le Raguenaud.

Formerly an agricultural commune, it became urbanized in the 1990s and many of its residents are now employed in nearby La Rochelle.