Saints' Rest was the second building erected on the campus of the Agricultural College of the State of Michigan (now Michigan State University).

It was built in 1856 and served as the school's only dormitory until 1870, when Williams Hall was completed.

It was only after the hall burned that it acquired the moniker "Saints' Rest", which came from the Puritan devotional The Saints' Everlasting Rest, written by Richard Baxter in 1650.

On June 6, 2005, a team of Michigan State archeology professors and students began a six-week excavation on the site.

The dig was part of MSU's 2005 sesquicentennial celebration.