This was the only full-length studio album with the band's original lineup since 1997's Generation Swine, following the return of drummer Tommy Lee, the last to feature guitarist Mick Mars before his dismissal from Mötley Crüe in 2022, and the last before their initial dissolution in 2015.

Frequent Aerosmith collaborator Marti Frederiksen also was heavily involved with the songwriting process.

[9] In a review for AllMusic, critic reviewer James Christopher Monger wrote: "Mötley Crüe have been trumpeting their hedonism for so long and so loudly that it's become more of a caricature than a way of life, and while Saints of Los Angeles is the best thing they've laid to tape since their codpiece heydays, it's more of a walk down memory lane/Sunset Strip than a legitimate call to arms.

Crüe Fest ran during the summer of 2008, with supporting bands Buckcherry, Papa Roach, Sixx:A.M., and Trapt.

[21] The Saints of Los Angeles Tour ran during early 2009 and supporting bands were Hinder, Theory of a Deadman, and The Last Vegas.

[6] The song was given further promotion through the music video game Rock Band, being released as downloadable content on the Xbox Live Marketplace and PlayStation Store on the same day.

Jacoby Shaddix from Papa Roach, Josh Todd from Buckcherry, Chris Brown from Trapt, and James Michael from Sixx:A.M. all make cameos at the end of the video.

Their previous nominations for "Dr. Feelgood" and "Kickstart My Heart" in the same category saw losses to Living Colour.