The Saitō clan (Japanese: 斎藤氏, Hepburn: Saitō-shi) was a Japanese samurai clan that ruled Mino province in the Sengoku period.

In 1530, Dōsan murdered the head of the Nagai clan and took control 1541, Dōsan attacked and overthrew the shugo of Mino province, Toki Yorinari.

He then adopted the name "Saitō" from a defunct samurai clan and set himself up as the daimyō of Mino.

This caused Yoshitatsu to rebel and kill his two younger brothers.

Tatsuoki was defeated by Oda Nobunaga in 1567, and the clan was extinguished.