In the Saiyuki Reload Priest Genjo Sanzo and companions Cho Hakkai, Sha Gojyo, and Son Goku maintain their westward journey to stop the resurrection of the demon Gyoumao.

As the reputation of the Sanzo Ikkou precedes them, they continue to fight demon assassins at every turn, but they must also deal with increasing tensions within their group in order to defeat a powerful enemy.

[6] Also a new anime series produced by Liden Films titled Saiyuki Reload: Zeroin has been announced on January 10, 2021.

[17][18] Animetion praised the first volume of the series gave it four stars out of five, described its animation as great with a rock music that supports the excellent characters.

[20] Nargis of Anime UK News gave an above average score to first volume of the series, called it brazen, stating that "it's [sic] attempts to be heartfelt comes across all wrong and what you get is a rather hilarious comedy.

[24] Don Houston of DVD Talk in his review of volume six, described Sanzo's team as cantankerous as ever, which makes them vulnerable due to disrespect and inability to adapt to each other.