In 1741 Tadamochi was appointed a sōshaban and jisha-bugyō simultaneously, and later the same year, he became Osaka-jō dai.
In 1754, the earliest recorded post-mortem examination in Japan was supervised by Tadamochi's personal physician.
This investigation by Kosugi Genteki (1730–1791) was considered highly controversial by his contemporary peers.
The autopsy involved an examination of the corpse of an executed criminal somewhere within the precincts of Jidoin Temple north of Nijō Castle; and the results were eventually published in Zoshi (Description of the Organs) in 1759.
He died in 1775 without male heir Tadamochi is buried with others of his clan at Kuin-ji in Obama in what is today Fukui Prefecture.