He has previously played in Major League Baseball (MLB) for the Cincinnati Reds, Milwaukee Brewers, and New York Yankees.

[2] The Cincinnati Reds selected Romano in the 23rd round of the 2011 Major League Baseball draft.

[4] After signing, Romano made his professional debut with the Billings Mustangs and he spent the whole season there, going 5–6 with a 5.32 ERA in 15 starts.

[5][6] He spent 2015 with the Daytona Tortugas and Pensacola Blue Wahoos,[7][8] compiling a combined 6–9 record and 4.82 ERA in 26 games (25 starts).

[21] On August 14, 2021, Romano signed a minor league contract to return to the New York Yankees.

[22] The Yankees selected his contract on September 8, and he made 1 appearance, getting 2 outs while giving up 1 run.

[23] On September 13, Romano cleared waivers, but rejected his outright assignment, making him a free agent.

[28] On April 12, 2023, Romano came out of retirement to sign with the Gastonia Honey Hunters of the Atlantic League of Professional Baseball.

On April 26, 2024, Romano signed a minor league contract with the Boston Red Sox.

[31] On July 26, 2024, Romano signed with the Long Island Ducks of the Atlantic League of Professional Baseball.

[32] In 8 games (6 starts) for Long Island, he compiled a 2–1 record and 4.72 ERA with 25 strikeouts across 34+1⁄3 innings pitched.