Salem Veteran Affairs Medical Center (VAMC) is a Veterans Affairs hospital located in Salem, Virginia.

Health care services are provided to veterans living in a 26-county area of Southwest Virginia.

In addition to the main facility in Salem, there are affiliated services in three community-based outpatient clinics.

These clinics are located in Danville, Lynchburg, Tazewell, Wytheville, and Staunton.

The Main Building (1934) is situated on a raised elevation over the front lawn and serves as the focal point of the historic district.