In 2023, along with Hekani Jakhalu Kense, Kruse became the first woman to be elected to the Nagaland Legislative Assembly.

[4] Kruse's husband, Kevisekho Kruse, joined Nationalist Democratic Progressive Party (NDPP) in 2018 and fought the Nagaland Legislative Assembly election that year from the Western Angami Assembly seat as the party candidate.

Nakhro in his condolence message stated, "He was a visionary leader full of impeccable knowledge, hopes, positive energy and keenly loved across by many for his lively nature and simplicity.

"[5] In the subsequent state elections, Salhoutuonuo Kruse was given the NDPP party ticket over sitting MLA Nakhro for the Western Angami seat.

With declared assets of over ₹129 million, she was in the top ten richest candidates standing for the state elections.

[10] By winning the seat, Kruse became one of the first elected women of the Nagaland Legislative Assembly alongwith Hekani Jakhalu.

"[4][12] During her first term as the Member of the Legislative Assembly, Kruse was appointed the Minister for Women Resource Development & Horticulture in the 5th Rio ministry.

She suggested improving intercultural practices and indigenous wisdom and integrate modern horticultural techniques and development.

She also encouraged villagers to cultivate other suitable crops with the assurance that the state's horticulture department with provide assistance in market linkages, technical knowledge, and other support.