Salice Salentino is a small town and comune in the southern part of Apulia, Italy, in the Salento area.

Main sights include the Chiesa Madre ("Mother Church") of Santa Maria Assunta (16th century) and the convent of the Friars Minor (1597-1597).

Its coat of arms features a tree in the middle of a shield and a golden crown on top.

Founded by the prince Raimondo Orsini Del Balzo in the end of the 14th century, Salice Salentino owes its name to the willow trees that once used to grow and populate its muddy, clay soil.

It was passed on to the marquis Albricci, Enriquez, prince of Squinzano, Filomarini, duke of Cutrofiano and della Torre.