The series ran for seven seasons on NBC as a part of the network's TNBC Saturday morning line-up, airing its final episode on January 8, 2000.

The first-season cast included Robert Sutherland Telfer, Jonathan Angel, Isaac Lidsky, Natalia Cigliuti, Bianca Lawson, and Bonnie Russavage.

Also present were Dennis Haskins as Principal Richard Belding, and Bob Golic from Saved by the Bell: The College Years as the resident advisor from Cal U.

The constant changes made it confusing for new viewers who were not watching the show from the start as cast members would come and go without any real explanation, and presumably contributed to lower ratings as the seasons progressed.

Brian Keller (Christian Oliver) became the new transfer student from Switzerland, Bobby Wilson (Spankee Rodgers) was the newest cool kid, and Rachel Meyers (Sarah Lancaster) was the school's fashion expert and shopaholic.

The writers also invited back original cast member Dustin Diamond as Screech for the show's second season, as he became available after the cancellation of Saved by the Bell: The College Years.

Providing continuity, Screech returned to Bayside High to work as Mr. Belding's assistant as part of a work/study program and also help build a bridge between the two series.

Prior to Season 3 cast members Bianca Lawson, Christian Oliver and Spankee Rodgers left the show, and three new characters were brought on.

New cast members Ben Gould (Nicky Farina), Lindsey McKeon (Katie Peterson), and Anthony Harrell (Eric Little) joined the show for its fourth season.

Season 6 followed and new cast member Tom Wade Huntington replaced Richard Lee Jackson as Tony Dillon, another Valley High transfer student and love interest for Maria.