The building was designed by C. Gadsen Sayre and built by L. S. Bradshaw, and (as Boyden High School) was added to the National Register of Historic Places on May 23, 1996.

[3] Six additional buildings were constructed on campus to facilitate the school's expanding offerings and enrollment, many of them as part of the Works Progress Administration.

The demographic group makeup of the student population was: Black, 54.05%; White, 32.84%; Hispanic, 11.19%; Asian/Pacific Islander, 1.92%; and American Indian, 0%.

[8] Salisbury High has nearly 180 students taking Advanced Placement courses, the most of any school in the district.

[10] The men's soccer team won the North Carolina 2A State Championship in 2011, defeating Carrboro High School 3–2 in sudden death overtime.