The building is largely of two stories and has a central main entrance; the architect was Sir William Tite, who was responsible for a number of LSWR stations.

[3] As the GWR and LSWR used different gauges, through goods traffic had to be unloaded and transhipped in a transfer shed; a covered footbridge was opened in 1860 linking the two stations, to allow passengers to change trains.

Isambard Kingdom Brunel provided a station with a wooden train shed to cover the tracks and a single-storey building of red brick with stone dressings to house booking offices and waiting rooms.

The train shed was demolished but Brunel's passenger buildings were designated as Grade II listed in 1972[6] and are in use as offices by non-railway businesses.

[5] In June 2024, Wiltshire Council began a project to refurbish the station's forecourt, using money from the government's Future High Streets fund.

The work included landscaping, lighting improvements and creation of a bus interchange, and most car parking would be relocated to a new facility on Fisherton Street.

An engine shed, water tower and turntable were erected on the Milford site from January 1847, as the line was then open for freight traffic.

[8] The sidings around the former GWR station were redeveloped in 1992 as Salisbury Traincare Depot, where South Western Railway maintain their fleet of DMUs.

[11] The approach road from the city is accessed from a junction on the south side of the railway bridge across Fisherton Street, which leads into a one-way car park with 287 spaces.

Behind this are the sidings of the Traincare Depot; at the east end of this is an old water tank and the brick offices which once served the GWR station.

South Western Railway operate half-hourly services to London Waterloo and hourly to Exeter St Davids.

[15] In 2022, South Western Railway added a "Welcome Host" at the station, a staff member who provides information and sells tickets.