Salles-sur-Garonne (French pronunciation: [sal syʁ ɡaʁɔn], literally Salles on Garonne; Occitan: Salas de Garona) is a commune in the Haute-Garonne department in southwestern France.

The commune is bordered by five other communes: Lafitte-Vigordane to the north, Carbonne to the northeast, Rieux-Volvestre across the river Garonne to the east, Saint-Julien-sur-Garonne to the south, and Saint-Élix-le-Château to the east.

The river Garonne flows through the commune, making the suffix -sur-Garonne, forming a border with Saint-Julien-sur-Garonne.

In 2010, Salles-sur-Garonne became a sister city of Lhatse, Tibet.

This Haute-Garonne geographical article is a stub.