Richardson also has appeared in a number of other films such as The Great White Hype (1996), Antwone Fisher (2002), Anacondas: The Hunt for the Blood Orchid (2004) and I Am Legend (2007).

[3] Her mother is of African American ancestry (with distant Cherokee roots), and her father was of English and Italian descent.

[2] She had many guest-starring roles in numerous television shows, such as Star Trek: Deep Space Nine, New York Undercover, The Pretender, Stargate SG-1, NYPD Blue, House, Bones, Criminal Minds, NCIS and Castle.

[7] Richardson starred opposite Dixie Carter and Kathleen Quinlan in the CBS legal drama series, Family Law, from 1999 to 2002.

[10] From 2006 to 2012, Richardson starred as Department of Defense agent (and later head of Global Dynamics) Allison Blake in the Syfy comedy-drama series Eureka.

[21] Her other notable directing credits include Chicago Med, Luke Cage, Black Lightning, The Punisher, American Gods, See and Altered Carbon.

[25] Richardson produces and had had directed episodes of HBO period drama The Gilded Age and Adam McKay's untitled Lakers project.

[25] Also in 2020, she directed the Zoom Where It Happens special The One with the Diverse Cast, a Friends one-night reboot starring Sterling K. Brown, Uzo Aduba, Ryan Michelle Bathe, Aisha Hinds, Kendrick Sampson and Jeremy Pope.