On Monday, October 22, 2001, Canal de las Estrellas started broadcasting Salomé weekdays at 8:00pm, replacing La intrusa.

The series stars Edith González, Guy Ecker, Sebastián Ligarde and Mónika Sánchez.

In the D'Ruby cabaret lives Salomé (Edith González), she is the main dancer of the show; her beauty and sensuality captivate the audience.

Near the cabaret there is a neighborhood where a series of characters live: There we get to know Kikis (Rosita Pelayo), a gossipy but cooperative woman; Hipólito (Jaime Garza), who is a plumber, but laziness and the inability to think about the future have made him mediocre; Marta (Paty Díaz), his wife, wants a better life, has aspirations and feels that her marriage is dying.

On the other side of the city, in a mansion, lives the Montesino family: Julio (Guy Ecker) and Ángela (Mónika Sánchez) are married.

She is a sick woman and her husband faces the problem and patiently bears the eventful marital life he is forced to live.

Lucrecia (María Rubio), Julio's mother, thinks that Ángela, being sterile, represents an obstacle for the family.

Salomé is simply a woman who loves with her eyes open and is aware that Julio is the man of her dreams, but he came late into her life.