According to the genealogical reconstructions, Salome had a brother called Khosrov III and a sister, name unknown, who married St. Husik I, one of the earlier Catholicoi of the Armenian Apostolic Church.
Mirian III established peaceful relations with the Roman Emperor Constantine the Great and Tiridates III, after Constantine declared Christianity as the official head religion of the Roman Empire.
In result of Mirian III's established relations, he arranged for Rev II to marry Salome[4] in 326.
Salome along with Perozhavra of Sivnia a noblewoman who was married to the ruler of the Kartli region, were the helpers and closest companions of Saint Nino.
As Salome and Perozhavra were women of influential social status[9] they both assisted Saint Nino in spreading the Christian faith.
After the whole Iberian royal family were converted to Christianity by Saint Nino from the orders of Mirian III, Salome erected a cross in Ujarma.
On her death bed, Saint Nino told Salome and Perozhavra her life story.