Download coordinates as: Salt Creek is a major tributary to the Sangamon River, which it joins at the boundary between Mason and Menard County, Illinois.

[2] There are at least two other Salt Creeks in Illinois, Salt Creek (Des Plaines River Tributary), and in Effingham County, Illinois.

[3] From its headwaters near Saybrook, Illinois, it runs generally westward to the main stem of the Sangamon near Greenview.

The lower reaches of Salt Creek at one time formed the boundary between Mason and Menard counties.

This stretch has been channelized so that the modern route of the creek only approximates the actual county line.