Saltasaurinae is a subfamily of titanosaurian sauropods known from the late Cretaceous period of South America, India and Madagascar.

[4] Saltasaurines lived in the late Cretaceous, from the early Campanian to the Maastrichtian (about 80–66 million years ago) when they went extinct along with all other non-avian dinosaurs.

An unnamed Saltasaurine from Madagascar would have probably survived later, until the Cretaceous-Paleogene extinction event, around 66 million years ago.

They defined the subfamily as "the clade including the most recent common ancestor of Neuquensaurus australis, Saltasaurus loricatus, and all of its descendants".

[7] In 2003, Jeffrey A. Wilson and Paul Upchurch elaborated on this definition to "all Saltasauridae more closely related to Saltasaurus loricatus than to Opisthocoelicaudia skaryzinskii".

Found only in the Campanian to Maastrichtian sediments of the Neuquén Basin, Salgado & Bonaparte (2007) decided a more restrictive clade was needed because of the expansion of Saltasaurinae as defined to include far more taxa than it originally encompassed.