Saluzzo (Italian: [saˈluttso]; Piedmontese: Salusse [saˈlyse]) is a town and former principality in the province of Cuneo, in the Piedmont region, Italy.

After Manfred II's death, his widow had to accept a series of tributes, which were to be later the base of the House of Savoy's claims over the increasingly feebler marquises' territories.

With the help of the French he resisted a vigorous siege by the Duke of Savoy in 1486, but in 1487 yielded and retired to France where he wrote L'art de la chevalerie sous Vegèce ("The art of chivalry under Vegetius", 1488), a treatise on good government, and other works on military affairs.

After long struggles for independence, the marquisate was occupied (1548) by the French, as a fief of the Crown of France – with the name of Saluces – and remained part of that kingdom until it was ceded to Savoy in 1601.

[4] The municipality of Saluces occupies a vast area of 7,659 ha (18,930 acres) in the Po Valley, about 35 km (22 mi) east of Mount Viso.

The Marquisate of Saluzzo was the seat of a Piedmontese principality whose history is closely linked to that of its powerful neighbor, the House of Savoy, until its definitive incorporation obtained in 1601 by Duke Charles Emmanuel.