He played in Major League Baseball (MLB) for the Toronto Blue Jays, Miami Marlins, Texas Rangers, San Francisco Giants, and Minnesota Twins.

[1] At the end of his sophomore year, he was selected in the 10th round of the 2009 Major League Baseball Draft, but decided to continue in college.

On July 19, Yan Gomes was called up to the Jays, and Dyson was sent back to Double-A New Hampshire after making 2 appearances over 2 weeks.

After making 2 more relief appearances, Dyson made his first major league start on September 16 against the Phillies, lasting only 2.2 innings, giving up 7 runs on 6 hits and 4 walks, striking out 1.

On October 8, 2015, Dyson made his postseason debut in Game 1 of the ALDS against his former team, the Blue Jays, earning the save.

[11] On June 6, 2017, the San Francisco Giants announced they had acquired Dyson from the Texas Rangers for a player to be named later.

[13] On July 31, 2019, the Giants traded Dyson to the Minnesota Twins in exchange for Jaylin Davis, Prelander Berroa, and Kai-Wei Teng.

On March 5, 2021, Dyson, a free agent at the time, was suspended for the entirety of the 2021 season after violating the off-the-field personal conduct policy, regarding a domestic violence case stemming back in 2019.

[17] After giving up the series-clinching home run to Toronto Blue Jays' right fielder José Bautista in game 5 of the 2015 American League Division Series, Dyson confronted Edwin Encarnación of the Blue Jays and informed him that he did not approve of Bautista's subsequent bat flip.

In explaining his actions afterwards, Dyson told reporters, "(Bautista)'s a huge role model for the younger generation that's coming up and playing this game.

The alleged victim, Alexis Blackburn, said in two lengthy Instagram posts that Dyson had bullied her and was violent towards both her and her cat during the time they were a couple.

On March 5, 2021, MLB suspended Dyson the entire 2021 season as a violation of the league's personal conduct policy.