Grewe contracted osteosarcoma on Christmas Eve of 2011 at the age of 13, which ultimately resulted in the amputation of his right leg via a unique procedure called rotationplasty.

Grewe jumped for the University of Notre Dame Track and Field Team, where he studied Pre-Med and resided in Fisher Hall on campus.

Sam began competing in high jump in 2014, two years after losing his leg to cancer.

In the following year, he competed at the 2016 Rio de Janeiro Paralympic Games,[4] where he earned a Silver Medal.

After graduating from high school in 2017, he attended the University of Notre Dame, where he competed on their varsity track & field team.