At the conclusion of the pre-draft process, Hubbard was projected to be a first or second round pick by NFL draft experts and scouts.

[21] On September 13, Hubbard recorded his first-career sack against the Baltimore Ravens, bringing down Joe Flacco for a loss of 11 yards in the 34–23 victory.

[24] In the Bengals' 2019 regular season opener, Hubbard recorded two sacks and a career-best 10 tackles in the 21–20 loss to the Seattle Seahawks.

[26] In Week 17 against the Cleveland Browns, Hubbard recorded a team high six tackles and sacked Baker Mayfield 1.5 times during the 33–23 win.

[28] In Week 3 against the Philadelphia Eagles, Hubbard recorded his first sack of the season on Carson Wentz during the 23–23 tie game.

[37] In the 2022 season, Hubbard finished with 6.5 sacks, 60 total tackles (34 solo), three passes defended, and one forced fumble in 15 games and starts.

[38] On January 15, 2023, in the Wild Card Round against the Ravens, Hubbard scored a 98-yard touchdown in the fourth quarter off of a fumble by Tyler Huntley that was forced by Logan Wilson.

On December 15, 2024, in Cincinnati's game against the Tennessee Titans, Hubbard scored his first career offensive touchdown on a two–yard reception from quarterback Joe Burrow.

[45] In recognition of his support for his community the Bengals selected him as their nominee for the Walter Payton NFL Man of the Year Award in 2021 and 2022.