He performed in concerts ranging from the Atlantic Records 40th anniversary party in 1988 to the New Orleans Jazz Festival and the SXSW Music Industry conference in 2006.

[1] Sam Moore and Dave Prater were both experienced gospel music singers, having performed separately with groups the Sensational Hummingbirds and the Melionaires.

They met in The King of Hearts Club in Miami in 1961, where they were discovered by regional producer Henry Stone, who signed them to Roulette Records.

Moore was at first disappointed not to be recording in the label's New York studios, but the Stax style of "gritty funk" turned out to be perfectly suited to their gospel-inspired vocals and enabled them to develop their "southern soul" sound.

[1] The duo's November 1965 single "You Don't Know Like I Know" started a series of 10 straight top-20 Billboard rhythm and blues (R&B) hits that included "Hold On!

"Soul Man", a message of black empowerment[1] written by Isaac Hayes and David Porter, backed by the label's house band Booker T and the MG's,[1] was a huge hit in 1967 and received a Grammy Award for Best R&B Performance.

[1] They had a reputation as a high-energy live act to rival Otis Redding, with whom they toured Britain and Europe in 1967, and a history of Stax described them as "double dynamite".

He formed a new act called "Sam's Soul Together 1970 Review" featuring singer Brenda Jo Harris and a 16-piece orchestra,[2] and released three singles on Atlantic Records in 1970 and 1971.

Sam appeared on Late Night with David Letterman with Junior Walker later that year and performed the song "Ordinary Man" from the film.

In 1991, Moore recorded several songs on Red, Hot & Blues with Republican Party official and avid bluesman Lee Atwater.

Shortly after the induction, Moore announced plans to record a solo LP, featuring duets with Bruce Springsteen, Phil Collins, and others.

The owners of the publishing rights to "Soul Man"'' did not agree with the claim that it was fair use of the song as a parody, and forced the campaign to stop using it.

In 1998, Moore appeared in the movie Blues Brothers 2000 playing the role of the Reverend Morris, fulfilling a childhood dream of being a preacher, and sang "John the Revelator".

[1][6] In January 2009, Moore performed with Sting and Elvis Costello at the Creative Coalition's Presidential Inaugural Ball for Barack Obama.

[7] In February 2009, Moore filed suit against Bob and Harvey Weinstein, the producers of the comedy film Soul Men, claiming that the story was based on the careers of Sam & Dave.

It was written (lyrics and music) in May 1968 by singer-songwriters Bobbejaan Schoepen (Belgium) and Jimmy James Ross (as Mel Turner, born in Trinidad-Tobago).

[11][12] On January 19, 2017, Moore sang a rendition of "America the Beautiful" at incoming President Donald Trump's inaugural concert in Washington, DC.

On September 1, 2017, aged 81, Moore performed live at the Royal Albert Hall BBC Proms in London with Jools Holland and his Rhythm & Blues Orchestra in a tribute concert to 50 years of Stax Records.

On January 26, 2018, Moore performed "Soul Man" live with Michael McDonald at the NAMM show in Anaheim, California, on the Yamaha Grand Stage.

On April 25, 2023, Moore joined a large cast of country performers honoring George Jones at the Still Playin' Possum concert at the Von Braun Center in Huntsville, Alabama, where he sang "The Blues Man".