In the mid-1920s, when he was employed in a Dallas music store, Price wrote to Paramount Records recommending Blind Lemon Jefferson to the label.

In 1938 he was hired by Decca Records as a session sideman on piano, assisting singers such as Trixie Smith and Sister Rosetta Tharpe.

Price was known for his work with his own band, known as the Texas Bluesicians (recorded by Decca), that included fellow musicians Don Stovall and Emmett Berry.

Price recorded under his own name, with gospel singers (Rosetta Tharpe, Evelyn Knight) and with Lester Young, toured Europe with Jimmy Rushing, appeared at many jazz festivals, and performed in a Broadway play starring Tallulah Bankhead (Clash By Night).

In the 1970s and 1980s, Price was a mainstay at the West End Bar on Broadway near Columbia University, working in a longstanding program of jazz produced by Phil Schaap.