Owned by the State Railway of Thailand, it is served by the Northern, Northeastern and Southern lines.

Sam Sen Station overlaps the area of Thanon Nakhon Chai Si Subdistrict, Dusit District, and Phaya Thai Subdistrict, Phaya Thai District, Bangkok.

The area near north side of the station was also the site of one of the first PDRC protests against the amnesty bill in the 2013–2014 Thai political crisis, used between 31 October to 4 November 2013.

It operates via these primary locations: Talat Phlu, Wongwian Yai, Pak Khlong Talat, Sanam Luang, Bang Lamphu, Wat Sam Phraya, Thewet, Saint Gabriel's College, Vajira Hospital and here, etc.

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