[1] In 2014, Strike guest starred in episode two of comedy series Give Out Girls as 15-year-old named Luke, whom Marilyn dates.
[3] In 2013, Strike was cast in his most famous role to date playing Johnny Carter in the BBC soap opera EastEnders.
In 2019, he was cast in the lead role of Roland Deschain in The Dark Tower for Amazon Studios, a pilot was shot, but the show was not picked up for a series.
In the same year, Strike starred opposite Sophie Thatcher and Chosen Jacobs in the Quibi coming of age series When the Streetlights Go On as the motorcycle riding town outcast Casper Tatum.
It was announced in 2022 that Strike had been cast in a starring role in the film adaption of The Boys in the Boat from Metro-Goldwyn-Mayer and directed by George Clooney.
In 2024, Strike will appear alongside Josh Brolin as Deputy Jess Chinlund in the second season of Amazon Studios' Outer Range and as Jay in Westhampton.