Brown's early career included working in commercials, notably playing the spokesperson "Wendy Wire" for a company called Century Cable.

[5] In addition to her regular shows, Brown hosted several Travel Channel specials, such as the 2006 all-access special Great Cruises: Freedom of the Seas with Samantha Brown aboard the Freedom of the Seas cruise ship, the largest passenger ship in the world at the time of its launch.

In 2007, she hosted a special titled Passport to Green Getaways, a travelogue to three eco-friendly destinations in North America.

[9] In 2008, Brown debuted Passport to Great Weekends, which showcased her in a more informal light as well as following her on more unique, off-the-beaten-path vacations.

Episodes would follow the format of her arrival at a destination on a Friday afternoon and conclude with her leaving on Sunday evening.

The second season's title was changed to Samantha Brown's Great Weekends and featured a new introduction, but mostly the same format.

The project later proved to be two sample episodes of Samantha Brown's Cash Attack, a travel-related game show.

[14] According to PBS, the series, first airing on January 6, 2018, features Brown seeking out "the little known spots and haunts where innovators and disrupters are creating a brand new travel experience.

Whether it's food and drink, art and design, culture or adventure, at the end of each episode viewers will have a well curated list of experiences that focus on not just how to visit a destination but how to belong to it.