[2] Hamadeh began his career as an associate at the Los Angeles management consulting firm L.E.K.

Before that, he co-founded and managed a customized textbook printing company, worked at Chevron Corporation, and co-authored The Internship Bible and America’s Top Internships published by Random House's Princeton Review imprint.

[4] In 1996, Hamadeh co-founded Vault.com and served as CEO[5] until the company was sold to the New York private equity firm Veronis Suhler Stevenson in October 2007.

[7] Hamadeh sits on the board of the non-profit PeaceWorks Foundation[8] and is or has been a board observer, angel investor and advisor in two dozen early-stage companies, including Directly, Campusfood.com (sold to GrubHub Seamless[9]), Crunched, Splurgy, and PublicStuff (now part of Accela[10]).

[3] Samer is also a mentor at several accelerators, including German Accelerator,[11] Lazaridis Institute,[12] Blueprint Health, NYCSeedStart, and First Growth Venture Network, as well as a member of Young Presidents' Organization[3] and the Executive Board of Venture for America.