There are numerous upgrades the phones possess over the previous models, in addition to improved specifications, an enhanced camera system supporting 8K video recording (7680×4320) at 24 frames per second, and a super-resolution zoom of 30–100x, for the Ultra model.

The S22 and S22+ contain comparable software, composition, and hardware to the previous year's models, with minor distinctions.

The S22 Ultra underwent massive reconstruction, with the phone serving as the successor to the discontinued Galaxy Note series.

The device features a rectangular body, higher resolution display, and advanced camera system, and most notably, the Ultra model houses an embedded S-Pen, a signature feature of the Note series.

The Galaxy S22 Ultra has a 6.8-inch (173 mm) screen and the largest battery capacity in the lineup, with a more advanced camera setup and a higher resolution display compared to the S22 and S22+, as well as an embedded S Pen – the first in the S Series as a whole.

All three models use Gorilla Glass Victus+ for the back panel, unlike the S21 series which had plastic on the smaller S21.

Except for some African and all European countries that use the Exynos 2200, with a new gpu with AMD, all models outside these regions use the Qualcomm Snapdragon 8 Gen 1 including Argentina, Australia, Canada, China, India, Mexico and the United States.

The phones also have the ability to charge other Qi-compatible devices from the S22's own battery power, which is branded as "Wireless PowerShare," at up to 4.5W.

[6] The Galaxy S22 series supports the following video modes:[6] Still frames extracted from high resolution footage can act as standalone photographs.

Samsung Knox is included for enhanced device security, and a separate version exists for enterprise use.

Testing performed by benchmarking utility Geekbench and media outlet Android Police reported that Samsung's Game Optimizing Service (GOS) was throttling the performance of the device significantly in a number of popular apps, but allowing it to run unthrottled for benchmarking utilities; one specific test on the S22+, using a copy of Geekbench 5 that was modified to look like Genshin Impact to the GOS, recorded a loss of 45% in single-core performance and 28% in multi-core performance versus an undisguised copy of the utility.