After publishing some prints in that county he moved to London.
With Nathaniel he embarked on making a number of series of prints of "antiquities", which consisted of ancient castles and former religious buildings in England and Wales.
Starting in 1724, they travelled around these countries, and completed sets of prints for the regions of England by 1738 and for Wales between 1739 and 1742.
During this time they also worked on a series of townscapes in England and Wales entitled Cities, Sea-ports and Capital Towns, often providing prospects from multiple directions.
Samuel died on 17 August 1779 in London and was buried in the churchyard of St. Clement Danes.