Samuel Charles Mazzuchelli, OP (November 4, 1806 – February 23, 1864) was a pioneer Italian Dominican friar and Catholic missionary priest who helped bring the Church to the Iowa-Illinois-Wisconsin tri-state area.

At the age of 17, he entered the Dominican Order, which was still recovering from the devastation wrought on the Catholic Church institutions in Italy under the French Revolutionary Army.

He was ordained a subdeacon in 1827 in the Lateran Basilica, around which time he was recruited to serve in new Diocese of Cincinnati, still missionary territory for the Church.

After spending some time in France to perfect his French, in 1828, Mazzuchelli set out for the United States, where he arrived in Cincinnati and was welcomed by the bishop, fellow Dominican friar, Edward Fenwick.

[3] Shortly after that, he was sent to serve at Sainte Anne Church on Mackinac Island and later in northern Wisconsin, After about five years there, Mazzuchelli arrived in the Dubuque area.

[9] The cause for elevating him to Sainthood started in 1964 when William Patrick O'Connor, the first Bishop of Madison, established a Diocesan Historical Commission to determine if documents available were sufficient for the Church to proceed with initial steps required in the process of beatification.

Robert Uselmann, a resident of Monona, Wisconsin, had gone to Sinsinawa Mound with his family in 2001 to pray for Mazzuchelli's intercession in curing him of cancer.

[3] Robert C. Morlino, Bishop of the Diocese of Madison, opened a diocesan tribunal at the Sinsinawa Dominican Sisters' request, which concluded its investigation and sent the results to Rome.