Benjamin had married Elizabeth (1656–1736), daughter of his first cousin Samuel Clarke (1626–1701), annotator of the Bible.
After reading the works of the elder Samuel Clark, who was both his paternal great-uncle and maternal great-grandfather, he went through a course of preparation for the ministry.
[1] Clarke was on intimate terms with Isaac Watts, Job Orton, and Philip Doddridge, the last of whom he had informally adopted as a recently orphaned thirteen-year-old.
[2] On Sunday 2 December 1750, whilst administering the Lord's Supper in his Dagnall Street chapel, Clarke suffered a stroke.
Clarke published some sermons, but is remembered for his Collection of the Promises of Scripture, arranged systematically.