His personal life was marked by a tumultuous marriage, multiple affairs, and cultural interests, including friendships with notable figures such as Sarah Bernhardt and Marcel Proust.

In the political arena, Pozzi served as a senator for his hometown, Bergerac, and supported Alfred Dreyfus during his trial.

She died when Samuel was ten, and his father then married an Englishwoman, Mary Anne Kempe, on 19 October 1859 in Bakewell, Derbyshire, England.

Later he was one of the pupils of the neurologist Paul Broca and as his assistant he worked with anthropology, neurology and comparative anatomy.

In 1876, Pozzi traveled to Scotland to the Congress of the British Medical Association to meet Joseph Lister, whose interest in antiseptics he supported.

He gained a reputation as a teacher, preferring to make his rounds dressed in white overalls and wearing a black cap.

In 1879, Pozzi married Thérèse Loth-Cazalis, heiress of a railroad magnate, and they had three children: Catherine, Jean, and Jacques.

Pozzi also had affairs: with the opera singer Georgette Leblanc, the actress Réjane, the widow of Georges Bizet, Sarah Bernhardt, and Emma Sedelmeyer Fischhof.

The daughter of an art dealer and wife of a horse breeder, Fischhof was a beautiful, cultured woman of Jewish heritage who became Pozzi's mistress in 1890.

[2][self-published source] In his early days in Paris, Pozzi had met Sarah Bernhardt through a childhood friend, the actor Jean Mounet-Sully.

Sketches by Clairin from when he painted murals on the walls of Pozzi's house are included in the illustrations in The Diva and Dr God (1).

Pozzi became an honorary member of the Cercle de l'Union artistique (known as the Mirlitons) in 1881, and met the painter John Singer Sargent.

[3] Sargent's 1881 portrait of Pozzi depicts him in a red dressing gown and is currently displayed at the UCLA Hammer Museum in Los Angeles.

He improved the water supply and sewer drainage of his town and was later involved with the restructuring of the French baccalaureate exams.

Pozzi witnessed the second trial of Alfred Dreyfus and supported Émile Zola, who wrote J'Accuse...!

[5] In 1874, Pozzi and Réné Benoit published a translation of Charles Darwin's The Expression of the Emotions in Man and Animals.

Caroline de Costa and Francesca Miller – Portrait of a Ladies’ Man- Dr Samuel-Jean Pozzi.